Physics + AI-Guided Design for Cell-Permeable Cyclic Peptide Discovery
Date:
Cyclic peptidomimetics occupy the sweet spot between small molecules and biologics, combining high target affinity with proteolytic stability and intrinsic cell penetration. However, their vast chemical space presents significant challenges for discovery. To address this, we (Atombeat Inc.) introduce RiDYMO.PepTx, a physics- and AI-guided platform that enables rational in silica design within an in silico cyclc peptide library constructed from more than 1000 natural and unatural amino acids. The platform integrates drug-likeness and permeability neural networks to prioritize candidates for rapid synthesis and testing.